Thermo Fisher Scientific IL36B Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

0.04-0.4 µg/mL

-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human IL36B. Recombinant protein control fragment (Product #RP-96089). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:IL36B,uniProtId:Q9NZH7-1,ncbiNodeId:9606,antigenRange:9-82,antigenLength:164,antigenImageFileName:PA5-57358_IL36B_Q9NZH7-1_Rabbit.svg,antigenImageFileNamePDP:PA5-57358_IL36B_Q9NZH7-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2642699

Product Specific Information

Immunogen sequence: PKSYAIRDSR QMVWVLSGNS LIAAPLSRSI KPVTLHLIAC RDTEFSDKEK GNMVYLGIKG KDLCLFCAEI QGKP

Highest antigen sequence identity to the following orthologs: Mouse - 61%, Rat - 64%.

Target Information

IL-36B is is a member of the interleukin 1 cytokine family whose gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. IL-36B is thought to activate the NF-kappaB pathway through IL-1 receptor family members IL-1RL2 and IL-1RAcP. Like the related proteins IL-36A and IL-36G, IL-36B requires post-translational processing for full agonist activity, but the cleavage mechanism is currently unknown. The IL-36 cytokines have been suggested to amplify Th1 responses by enhancing proliferation and Th1 polarization of naive CD4+ T cells.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.