Thermo Fisher Scientific IL36B Polyclonal Antibody
Human IL36B 단백질에 특이적인 Rabbit Polyclonal Antibody로, WB 및 IHC(P) 분석에 적합. 항원 친화 크로마토그래피로 정제되었으며, PBS와 글리세롤 버퍼에 보관. NF-κB 경로 연구 및 IL-36 사이토카인 관련 면역 연구에 활용 가능.
- 카탈로그번호
- PA557358
- 판매단위
- pk
카탈로그
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human IL36B. Recombinant protein control fragment (Product #RP-96089). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2642699 |
Product Specific Information
Immunogen sequence:
PKSYAIRDSR QMVWVLSGNS LIAAPLSRSI KPVTLHLIAC RDTEFSDKEK GNMVYLGIKG KDLCLFCAEI QGKP
Highest antigen sequence identity to the following orthologs:
- Mouse: 61%
- Rat: 64%
Target Information
IL-36B is a member of the interleukin 1 cytokine family. Its gene, along with eight other interleukin 1 family genes, forms a cytokine gene cluster on chromosome 2. IL-36B is thought to activate the NF-kappaB pathway through IL-1 receptor family members IL-1RL2 and IL-1RAcP. Like IL-36A and IL-36G, IL-36B requires post-translational processing for full agonist activity, though the cleavage mechanism remains unknown. IL-36 cytokines may amplify Th1 responses by enhancing proliferation and Th1 polarization of naive CD4+ T cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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