Thermo Fisher Scientific Phospho-CREB (Ser133) Recombinant Rabbit Monoclonal Antibody (CREBS133-4D11), APC

Applications

• Flow Cytometry (Flow): 5 µL / 1×10⁶ cells
• View 1 publication

Product Specifications

Additional Formats

• Unconjugated (MA5-36989)
• FITC (MA5-36991)
• PE (MA5-36990)
• Request custom conjugation

Product Specific Information

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems developed by cloning specific antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select the best candidates for production.

Advantages:

• Superior specificity and sensitivity
• Lot-to-lot consistency
• Animal origin-free formulation
• Broad immunoreactivity due to large rabbit immune repertoire

Target Information

CREB (Cyclic AMP response element binding protein) is a 43 kDa basic/leucine zipper transcription factor that binds the cyclic AMP response element (CRE) and activates transcription in response to extracellular signals such as neurotransmitters, hormones, membrane depolarization, and growth factors.

Activation of CREB depends on phosphorylation at serine 133 via p44/42 MAP kinase, p90RSK, p38 MAP kinase, and MSK1. Although CREB binds DNA regardless of phosphorylation, only the phosphorylated form functions as a transcription factor. CREB interacts with CREB binding protein (CBP) at the serine 133 region.

CREB is involved in:

• Circadian rhythm synchronization
• Adipocyte differentiation
• Learning and memory

In humans, the CREB gene is located on chromosome 2q. Dysregulation of CREB is associated with Alzheimer's disease, histiocytoma, and soft tissue melanoma.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.

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