Thermo Fisher Scientific CD4 Monoclonal Antibody (10C12)
인간 CD4 단백질의 세포질 말단을 인식하는 Mouse IgG1 단일클론 항체입니다. Western blot, ELISA, IHC, ICC/IF에 적합하며, 단백질 G로 정제된 액상 형태로 제공됩니다. 연구용으로 HIV 및 면역세포 관련 연구에 활용 가능합니다.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 5–10 µg/mL | - |
| Immunohistochemistry (IHC) | – | View 1 publication |
| Immunocytochemistry (ICC/IF) | 5–10 µg/mL | - |
| ELISA | 10–20 µg/mL | - |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 10C12 |
| Immunogen | Synthetic peptide corresponding to residues LSEKKTCQCPHRFQKTCSPI of human CD4 (aa 440–458) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.55 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | –20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_1072330 |
Product Specific Information
MA1-10800 detects CD4 Cytoplasmic Tail from human samples.
It has been successfully used in ELISA, immunofluorescence, and Western blot applications.
The immunogen is a synthetic peptide corresponding to residues LSEKKTCQCPHRFQKTCSPI of human CD4.
Target Information
The CD4 antigen is involved in the recognition of MHC class II molecules and acts as a co-receptor for HIV.
CD4 is primarily expressed in T helper cells but may also be found in monocytes, macrophages, and dendritic cells.
Tissue-level expression includes thymus, lymph nodes, tonsils, spleen, and certain regions of the brain and gut.
CD4 functions to initiate or augment T-cell activation through association with the T-cell receptor complex and Lck kinase.
It may also mediate neuronal damage in infectious and immune-mediated CNS diseases.
Multiple alternatively spliced transcripts have been identified (RefSeq, July 2017).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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