Thermo Fisher Scientific EPOR Monoclonal Antibody (3D10)
인간 EPOR 단백질에 특이적인 Mouse IgG2b 단클론 항체. Western blot, ELISA, IP에 사용 가능. Affinity chromatography로 정제된 액상 시약. PBS(pH 7.4) 저장, 방부제 무첨가. 연구용으로만 사용.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–5 µg/mL |
| ELISA | 0.03 ng/mL |
| Immunoprecipitation (IP) | 1–5 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 3D10 |
| Immunogen | EPOR (NP_000112, 31 a.a. – approximately 130 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 kDa. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | −20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Protein Sequence:
PDPKFESKAA LLAARGPEEL LCFTERLEDL VCFWEEAASA GVGPGNYSFS
YQLEDEPWKL CRLHQAPTAR GAVRFWCSLP TADTSSFVPL ELRVTAASGATarget Information
EpoR encodes the erythropoietin receptor, a member of the cytokine receptor family. When erythropoietin binds to this receptor, it activates the Jak2 tyrosine kinase, which subsequently triggers intracellular signaling pathways including Ras/MAP kinase, phosphatidylinositol 3-kinase, and STAT transcription factors. Activation of the erythropoietin receptor promotes erythroid cell survival. Mutations in this gene can cause erythroleukemia and familial erythrocytosis. Dysregulation may also influence tumor growth. Multiple transcript variants are produced via alternative splicing.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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