Thermo Fisher Scientific Human Amyloid Precursor Protein Synthetic Peptide
인간 아밀로이드 전구체 단백질(APP) 유래 합성 펩타이드로, 항체 차단 및 대조 실험에 사용 가능. 17개 아미노산 서열로 구성되며, 액상 형태로 제공. APP 관련 신경세포 성장 및 알츠하이머 연구에 활용. 연구용 전용 시약.
- 카탈로그번호
- PEP0851
- 카테고리
- Protein
- 판매단위
- pk
카탈로그
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Applications
Control (Ctrl)
- Assay-dependent
Blocking Assay (BLOCK)
- Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
Product Specific Information
This peptide corresponds to 17 amino acids near the amino terminus of human APP.
PEP-0851 can be used as a blocking peptide with polyclonal antibody PA5-20737.
Target Information
Amyloid Precursor Protein (APP) or Amyloid beta precursor protein functions as a cell surface kinesin I membrane receptor, mediating the axonal transport of beta-secretase and presenilin 1.
APP is important for neurite growth, neuronal adhesion, and axonogenesis. It is a 100–140 kDa transmembrane glycoprotein that exists as several isoforms resulting from alternative splicing.
Proteolytic cleavage of APP by beta- and gamma-secretases generates beta amyloid, the primary component of senile plaques—one of the major histopathologic features of Alzheimer’s disease.
Abnormal regulation and processing of APP also play a role in Down’s syndrome, early-onset familial Alzheimer’s disease, and cerebral hemorrhage.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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