Thermo Fisher Scientific IGF1 Monoclonal Antibody (M23/ILG1-001)

Applications and Tested Dilution

ELISA

• Dilution: Assay-dependent

Radioimmune Assays (RIA)

• Dilution: Assay-dependent

Product Specifications

Product Specific Information

This product has an affinity of 10^8–10^9 L/mole.

Target Information

IGF1 (Insulin-like growth factor-1) is structurally and functionally related to insulin but has a much higher growth-promoting activity. It induces various cellular responses such as proliferation, differentiation, migration, and survival. IGF1 stimulates the proliferation of cell types in muscle, bone, and cartilage tissues and promotes glucose transport in osteoblastic cells at lower concentrations than insulin.
In circulation, IGFs are bound to IGF binding proteins (IGFBPs), which extend their half-life and facilitate delivery to target tissues. IGF-I is a potent activator of the AKT signaling pathway, promoting proliferation and inhibiting apoptosis. Mature human IGF-I is 100% homologous with bovine and porcine proteins. Low IGF1 levels have been associated with Alzheimer’s disease.
Defects in the IGF1 gene cause insulin-like growth factor 1 deficiency, and multiple transcript variants encoding different isoforms have been identified.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.