Thermo Fisher Scientific Integrin beta 7 Monoclonal Antibody (473207), FITC
인간 Integrin beta 7을 인식하는 마우스 단클론 항체로, FITC로 표지되어 유세포분석(Flow Cytometry)에 적합합니다. 단백질 A/G로 정제되었으며, 4°C 암소 보관이 필요합니다. 교차반응이 거의 없고 높은 특이성을 제공합니다.
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Applications
Flow Cytometry (Flow)
- 사용량: 10 µL per million cells
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 473207 |
| Immunogen | CHO-derived recombinant human Integrin beta 7 long isoform (Glu20–His723) |
| Conjugate | FITC |
| Excitation/Emission Max | 498 / 517 nm |
| Form | Liquid |
| Purification | Protein A/G |
| Storage buffer | Buffered saline solution with BSA |
| Contains | 0.09% sodium azide |
| Storage conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2609114 |
Additional Formats
- Unconjugated (MA5-24192)
- PE (MA5-23541)
- Custom conjugation available on request
Product Specific Information
In Western blots, no cross-reactivity with recombinant human Integrin beta 1, beta 2, beta 3, beta 4, beta 5, beta 6, beta 8, recombinant mouse Integrin beta 4, or beta 7 is observed.
Target Information
Integrin beta 7 associates with integrin alpha 4 (CD49d) to form the alpha 4 beta 7 integrin (LPAM-1), expressed on intraepithelial lymphocytes. It also associates with alpha E (CD103) to form the alpha E beta 7 integrin (HML-1), expressed on T cells adjacent to mucosal epithelium and intraepithelial lymphocytes.
Ligands for LPAM-1 include VCAM-1 (CD106), MAdCAM-1, and fibronectin, while the ligand of HML-1 is E-cadherin (CD324).
Integrin beta 7 plays an important role in leukocyte adhesion to endothelial cells, promoting transmigration during the inflammatory response.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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