Thermo Fisher Scientific Tat epitope 1 Monoclonal Antibody (ABM029)
HIV-1 Tat 단백질을 특이적으로 인식하는 Mouse IgG1 단클론 항체입니다. IHC(P) 및 ELISA에 사용 가능하며, 단백질 A로 정제된 액상 형태로 제공됩니다. 연구용으로만 사용되며, 장기 보관 시 -20°C에서 보관 권장.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 2–10 µg/mL
ELISA
- Tested Dilution: 0.01–0.1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Virus |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | ABM029 |
| Immunogen | TAT Recombinant Protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS with proprietary stabilizer |
| Contains | 0.01% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive control: TAT Recombinant Protein
Target Information
HIV-1 Tat (Trans-Activator of Transcription) consists of 86 to 101 amino acids depending on the subtype.
Tat is critical to HIV reproduction by compensating for a defect in its genome: the HIV RNA initially has a hairpin-structured portion which prevents full transcription.
A small number of RNA transcripts allow Tat protein production. Tat binds to and phosphorylates cellular factors, eliminating the hairpin RNA structure effect and enabling full transcription of HIV RNA.
This enhances transcription rate through a positive feedback cycle. The protein is released by infected cells and found in the blood of HIV-1 infected patients.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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