Thermo Fisher Scientific TNFSF9 Monoclonal Antibody (2A1)

Applications

• ELISA (ELISA): Tested dilution 10 µg/mL

Product Specifications

Product Specific Information

Sequence of this protein is as follows:
ACPWAVSGAR ASPGSAASPR LREGPELSPD DPAGLLDLRQ GMFAQLVAQN VLLIDGPLSW YSDPGLAGVS LTGGLSYKED TKELVVAKAG VYYVFFQLEL RRVVAGEGSG SVSLALHLQP LRSAAGAAAL ALTVDLPPAS SEARNSAFGF QGRLLHLSAG QRLGVHLHTE ARARHAWQLT QGATVLGLFR VTPEIPAGLP SPRSE

Target Information

CD137 ligand (CD137L) is a type II membrane protein and part of the TNF superfamily. CD137L is a co-stimulatory molecule expressed on antigen-presenting cells (DCs, monocytes/macrophages, B cells) and is upregulated upon activation.
Its receptor, CD137/4-1BB, is found on various cells, including inflamed endothelial cells, where expression enhances extravasation of CD137L-expressing monocytes. Activated T cells also express CD137, and engagement with CD137L enhances T cell proliferation, IL-2 secretion, survival, and cytotoxic activity.
CD137L is expressed on most B-cell lymphomas (mantle cell, follicular, diffuse large B-cell lymphoma) but absent in Hodgkin and T-cell lymphomas. It is also expressed in carcinoma cell lines and is thought to be involved in T cell–tumor cell interactions.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.