Thermo Fisher Scientific Synaptophysin Monoclonal Antibody (SYP, 3551)

Applications

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1–2 µg/mL

Peptide Array (Array)

• Tested Dilution: Assay-dependent

Product Specifications

Product Specific Information

• Immunohistochemistry (PFA fixed): incubate antibody for 30 min at room temperature (RT).
• Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C, followed by cooling at RT for 20 min.

Target Information

Synaptophysin is a calcium-binding integral membrane glycoprotein present in presynaptic vesicles of nearly all neurons. It has four transmembrane domains and forms a complex with dynamin at high calcium concentrations, suggesting a role in synaptic vesicle endocytosis. Synaptophysin is involved in regulating short- and long-term synaptic plasticity and is widely used as a marker for nerve terminals and neuroendocrine tumors. Mutations in the gene can lead to X-linked mental retardation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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