Thermo Fisher Scientific TPPP Polyclonal Antibody
TPPP 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot, IHC, ICC, ELISA 등 다양한 응용 가능. Human, Mouse, Rat 반응성. Protein A로 정제된 고순도 항체로 안정적인 액상 형태 제공.
- 카탈로그번호
- BS-11674R
- 판매단위
- pk
카탈로그
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Thermo Fisher Scientific TPPP Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:500 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human TPPP, amino acids 61–150 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | −20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Tubulin family members are globular proteins important in the assembly of microtubules. Microtubules are structural components that play critical roles in mitosis, cytokinesis, and vesicle transport.
TPPP (Tubulin polymerization-promoting protein), also known as p24 and p25, is a widely expressed 219 amino acid protein found in the perinuclear region of the cytoplasm.
TPPP may form dimers and functions in polymerizing tubulin into double-walled tubules, polymorphic aggregates, or stabilized blocks. Overexpression of TPPP prevents formation of the mitotic spindle assembly and breakdown of the nuclear envelope.
TPPP is phosphorylated by TPK II and is encoded by a gene that maps to human chromosome 5, which contains about 181 million base pairs and comprises nearly 6% of the human genome.
It may play a role in tubulin polymerization into microtubules, microtubule bundling, and stabilization of existing microtubules, thus maintaining the integrity of the microtubule network, as well as in mitotic spindle assembly and nuclear envelope breakdown.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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