Thermo Fisher Scientific IDH3G Polyclonal Antibody

Thermo Fisher Scientific IDH3G Polyclonal Antibody

Applications

• Immunohistochemistry (Paraffin) (IHC (P)): 1:100–1:1,000

Product Specifications

Product Specific Information

• Keep as concentrated solution.
• Predicted reactivity: Mouse (98%), Rat (99%), Xenopus laevis (85%), Rabbit (98%), Bovine (98%).
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one utilizing NAD(+) and the other NADP(+) as electron acceptors.
Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent (mitochondrial matrix localized) and two NADP(+)-dependent (one mitochondrial, one cytosolic).
NAD(+)-dependent isocitrate dehydrogenases catalyze the allosterically regulated rate-limiting step of the tricarboxylic acid cycle. Each isozyme is a heterotetramer composed of two alpha, one beta, and one gamma subunit.
The protein encoded by this gene is the gamma subunit of one NAD(+)-dependent isozyme and is a candidate gene for periventricular heterotopia. Several alternatively spliced transcript variants have been described.

Safety Information

⚠ WARNING: This product can expose you to chemicals including mercury, known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

Usage Notice

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.