Thermo Fisher Scientific SDPR Polyclonal Antibody
SDPR 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, WB, IHC, ELISA, IP 등 다양한 응용 가능. 인간 반응성, 고순도 친화 크로마토그래피 정제, 안정적인 액상 형태. 연구용으로만 사용.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:500 |
| ELISA | 1:20,000–1:60,000 |
| Immunoprecipitation (IP) | 1 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | SDPR affinity purified antibody prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to the C-terminal region of human SDPR. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.02 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | 0.02M potassium phosphate, pH 7.2, with 0.15M NaCl, 50% glycerol |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Store vial at -20°C prior to opening. Aliquot contents and freeze at -20°C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use.
Anti-SDPR antibody is specific towards Cavin 2 SDR. A BLAST analysis suggests cross-reactivity with human SDPR based on 100% sequence homology. Cross-reactivity with SDPR from other sources has not been determined.
Target Information
The serum deprivation-response protein (SDPR) is a calcium-independent phospholipid-binding protein whose expression increases in serum-starved cells. SDPR is a substrate for protein kinase C (PKC) phosphorylation and recruits the polymerase I and transcript release factor (PTRF) to caveolae. Removal of SDPR causes caveolae loss, while over-expression results in caveolae deformation and membrane tubulation. Both SDPR and PTRF, as well as PRKCDBP, are downregulated in breast cancer cell lines and tumor tissue, suggesting cavin family protein expression may serve as a prognostic indicator of breast cancer progression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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