Thermo Fisher Scientific DFFB Polyclonal Antibody
Thermo Fisher Scientific의 DFFB Polyclonal Antibody는 인간, 마우스, 랫트에서 반응하며 다양한 면역학적 응용에 적합합니다. KLH 결합 합성 펩타이드로 면역화된 Rabbit IgG 기반의 비결합 폴리클로날 항체입니다. 단백질 A로 정제되었으며, 액상 형태로 -20°C에서 보관합니다.
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Thermo Fisher Scientific DFFB Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:400 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human DFFB, amino acids 251–338 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Caspase-activated DNase (CAD) cleaves chromosomal DNA during apoptosis. Apoptosis, a cell death process that removes toxic and/or useless cells during mammalian development, can be induced by various stimuli such as death factors of the tumor necrosis factor family, UV irradiation, anticancer drugs, and survival factor deprivation.
During apoptosis, cells and nuclei shrink and fragment, and chromosomal DNA is degraded into nucleosomal units. CAD, activated by caspases, exists as a complex with its inhibitor ICAD. ICAD assists in proper folding of CAD and inhibits its DNase activity. Upon activation, caspase cleaves ICAD, releasing CAD to enter the nucleus and cleave DNA.
Apoptosis regulation involves a balance among pro- and anti-apoptotic proteins of the Bcl-2 family, heat shock proteins, and inhibitors of apoptosis proteins (IAPs). Fourteen members of the caspase family have been identified, seven of which mediate apoptosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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