Thermo Fisher Scientific DFFB Polyclonal Antibody

Thermo Fisher Scientific DFFB Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Target Information

Caspase-activated DNase (CAD) cleaves chromosomal DNA during apoptosis. Apoptosis, a cell death process that removes toxic and/or useless cells during mammalian development, can be induced by various stimuli such as death factors of the tumor necrosis factor family, UV irradiation, anticancer drugs, and survival factor deprivation.
During apoptosis, cells and nuclei shrink and fragment, and chromosomal DNA is degraded into nucleosomal units. CAD, activated by caspases, exists as a complex with its inhibitor ICAD. ICAD assists in proper folding of CAD and inhibits its DNase activity. Upon activation, caspase cleaves ICAD, releasing CAD to enter the nucleus and cleave DNA.
Apoptosis regulation involves a balance among pro- and anti-apoptotic proteins of the Bcl-2 family, heat shock proteins, and inhibitors of apoptosis proteins (IAPs). Fourteen members of the caspase family have been identified, seven of which mediate apoptosis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

제품 이미지

(이미지 없음)