Thermo Fisher Scientific Phospho-p23 (Ser113) Polyclonal Antibody
Phospho-p23 (Ser113) 폴리클로날 항체로, Human, Mouse, Rat 시료에서 사용 가능. WB, IHC, ICC, ELISA 등 다양한 응용에 적합. Protein A로 정제된 고순도 항체로 안정적이며, -20°C에서 보관. 연구용으로만 사용.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:100–1:500 |
| Immunohistochemistry (Frozen) (IHC-F) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Item | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic phosphopeptide derived from human Telomerase Binding Protein P23 around the phosphorylation site of Ser113 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01 M TBS, pH 7.4, with 1% BSA, 50% glycerol |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | −20 °C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Steroid receptors are ligand-dependent intracellular proteins that stimulate transcription of specific genes by binding to DNA sequences following activation by the appropriate hormone.
Prior to activation, steroid receptors associate with various proteins, including heat shock proteins (HSP70, HSP90), immunophilins (FKBP52, FKBP54, CyP-40), and other proteins such as p23, p60, and p48.
p23, together with HSP70, HSP90, and p60, forms a transient intermediate complex with the progesterone receptor (PR).
Human p23 encodes a 160-amino-acid protein that is highly conserved across species and is a highly acidic phosphoprotein containing multiple phosphorylation sites.
In vitro studies suggest that p23 binds to HSP90 and is essential for the interaction between HSP90 and CyP-40 with PR.
Although its exact function is not fully defined, p23 is considered an important factor in PR function.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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