Thermo Fisher Scientific Trastuzumab Recombinant Human Monoclonal Antibody (4D5-8 (trastuzumab))
HER2 단백질을 표적으로 하는 인간 재조합 단일클론 항체. IHC, Flow Cytometry, ELISA에 사용 가능. HEK293 세포에서 발현된 IgG1 kappa 형식. 단기 4°C, 장기 -20°C 보관 권장. 연구용으로만 사용.
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Thermo Fisher Scientific Trastuzumab Recombinant Human Monoclonal Antibody (4D5-8, trastuzumab)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (IHC) | Assay-dependent |
| Flow Cytometry (Flow) | Assay-dependent |
| ELISA | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Human / IgG1, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 4D5-8 (trastuzumab) |
| Immunogen | A431 cells (human epidermoid carcinoma) overexpressing EGFR |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3074204 |
Product Specific Information
Specificity: Oncogenic protein Her-2/neu (erbB-2), a member of the epidermal growth factor receptor family. It is overexpressed in approximately 30% of invasive breast cancers, 70% of ductal carcinomata in situ, and in a subset of melanomas and other malignancies originating from ovary, kidney, colon, and bladder.
Target Information
Trastuzumab (Herceptin) is an FDA-approved drug for HER2-targeted therapy in breast cancer. It is a recombinant humanized monoclonal antibody (IgG1 kappa) that binds to the HER2 receptor on HER2-positive tumor cells, inhibiting cell growth and proliferation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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