
Thermo Fisher Scientific Trastuzumab Chimeric Recombinant Rabbit Monoclonal Antibody (4D5-8 (trastuzumab))
HER2/neu 표적 연구용 재조합 토끼 단일클론 항체로, IHC, Flow Cytometry, ELISA 등에 사용 가능. 인간 반응성, HEK293 발현 시스템 사용. Protein A 정제, 1 mg/mL 농도, PBS 버퍼에 ProClin 300 포함. 단기 4°C, 장기 -20°C 보관.
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Thermo Fisher Scientific Trastuzumab Chimeric Recombinant Rabbit Monoclonal Antibody (4D5-8 (trastuzumab))
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 4 µg/mL |
| Flow Cytometry (Flow) | Assay-dependent |
| ELISA | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 4D5-8 (trastuzumab) |
| Immunogen | A431 cells (human epidermoid carcinoma) overexpressing EGFR |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3074205 |
Product Specific Information
Specificity: Oncogenic protein Her-2/neu (erbB-2), a member of the epidermal growth factor (EGF) receptor family. Overexpressed in approximately 30% of invasive breast cancers, 70% of ductal carcinomata in situ, and in some melanomas and other malignancies originating from ovary, kidney, colon, and bladder.
Target Information
Trastuzumab (Herceptin) is an FDA-approved drug for HER2-targeted breast cancer therapy. It is a recombinant humanized monoclonal antibody (IgG1 kappa) that binds to the HER2 receptor on HER2-positive tumor cells, suppressing their growth and proliferation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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