Thermo Fisher Scientific CD68 Polyclonal Antibody

Applications

Immunohistochemistry (IHC)

• Tested Dilution: -
• Publications: View 2 publications

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:1,000–1:4,000
• Publications: View publications

ELISA

• Tested Dilution: 1:5,000–1:10,000
• Publications: View publications

Product Specifications

Product Specific Information

This product is preservative-free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%–0.1%).
This antibody has specificity for Rat CD68.

Target Information

CD68 (Macrosialin) is a 110 kDa integral membrane glycoprotein predominantly expressed on the intracellular lysosomes of monocytes and macrophages, and to a lesser extent by dendritic cells and peripheral blood granulocytes.
It may play a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions.
CD68 is expressed by interdigitating reticulum cells in tonsil and some histiocytic lymphoma or histiocytosis, acute myeloid leukemia (AML), and granulocytic sarcoma.
Elevated expression of CD68 has been demonstrated on CD34+ cells in various human malignancies, including several AML studies.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.