Thermo Fisher Scientific FAIM3 Polyclonal Antibody
FAIM3 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체로, Western blot, IHC, ICC, ELISA 등 다양한 응용에 사용 가능. Human, Mouse, Rat 반응성. Protein A 정제, 1 mg/mL 농도, -20°C 보관.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | Assay-dependent |
| Immunohistochemistry (Frozen) (IHC-F) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic peptide derived from human FAIM3 (amino acids 61–160) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Apoptosis is an essential process for maintaining normal tissue homeostasis and function. One of the key regulatory pathways involves activation of the Fas receptor by its ligand, leading to formation of a Fas-associated death domain (FADD)-containing death-inducing signaling complex and activation of caspase-8. This enzyme subsequently activates downstream effector caspases such as caspase-3 and -7.
Overexpression of Toso (FAIM3), a novel regulator of Fas-induced apoptosis in lymphoid cells, has been shown to make Jurkat cells and transgenic mice resistant to Fas-induced apoptosis but not to TRAIL-induced apoptosis. Toso associates with FADD, suggesting it disrupts the formation of the death-inducing signaling complex.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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