Thermo Fisher Scientific CCDC106 Polyclonal Antibody
Human CCDC106 단백질을 인식하는 Rabbit Polyclonal 항체로, WB, IHC(P), ICC/IF에 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, PBS buffer(40% glycerol) 내 액상 형태로 제공. p53 조절 관련 연구용에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:2,500–1:5,000 |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human CCDC106. Recombinant protein control fragment (Product #RP-99161). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.3 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2639357 |
Product Specific Information
Immunogen sequence:
KLKSMSRAFE HHRVDRNTVA LTTPIAELLI VAPEKLAEVG EFDPSKERLL EYSRRCFLAL DDETLKKVQA LKKSKLLLPI TYRFK
Highest antigen sequence identity to the following orthologs:
Mouse – 100%, Rat – 100%.
Target Information
The coiled-coil domain is a common protein motif often involved in protein oligomerization and is found in proteins such as transcription factors and intermediate filaments.
CCDC106 was initially identified as a p53-interacting protein by yeast two-hybrid screening. Other experiments demonstrated that CCDC106 co-localizes and interacts with p53 in the nucleus, inhibiting the transcriptional activity of p53 and stimulating p53 protein degradation.
This indicates that one of the functions of CCDC106 is acting as a negative regulator of p53.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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