Thermo Fisher Scientific IGFBP5 Polyclonal Antibody

Applications

• Western Blot (WB): Tested at 1.0 µg/mL

Product Specifications

Product Specific Information

This target displays homology in the following species:
Cow: 100%; Dog: 100%; Goat: 100%; Guinea Pig: 86%; Horse: 93%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 100%; Rat: 100%; Sheep: 100%

Target Information

The insulin-like growth factor-binding proteins (IGFBPs) are a family of homologous proteins that co-evolved with the IGFs. They act as shuttle molecules for soluble IGFs and regulate IGF signaling by influencing growth factor bioavailability and distribution. IGFBPs also exhibit IGF-independent biological activity.
Seven IGFBPs have been identified, each differing in tissue distribution, half-life, and modulation of IGF-receptor interactions. For example:

• IGFBP1 is negatively regulated by insulin and highly expressed during fetal liver development.
• IGFBP2 may function as a chaperone, expressed in fetal eye and brain.
• IGFBP3 is the most abundant form, binding ~80% of serum IGFs.
• IGFBP4 is released by dermal fibroblasts after incision injury.
• IGFBP5 is secreted by myoblasts and may play a key role in muscle differentiation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.