Thermo Fisher Scientific CD229 Recombinant Rabbit Monoclonal Antibody (017)

Applications

• ELISA (ELISA)
  Tested Dilution: 1:5,000–1:10,000

Product Specifications

Product Specific Information

This product is preservative free. It is recommended to add sodium azide (final concentration 0.05%–0.1%) to avoid contamination.

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems developed by cloning specific antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select the best candidates for production.

Advantages of recombinant rabbit monoclonal antibodies:

• Better specificity and sensitivity
• Lot-to-lot consistency
• Animal origin-free formulations
• Broader immunoreactivity due to larger rabbit immune repertoire

This antibody has specificity for Mouse LY9/CD229/SLAMF3.

Target Information

CD229 (Ly9) is a cell surface receptor of the CD150 family, which also includes CD48 and CD224. Receptors of this family regulate cytokine production and cytotoxicity of lymphocytes and NK cells.

High levels of CD229 are found on T and B cells, with expression increasing during maturation. It is absent on granulocytes, bone marrow-derived dendritic cells, platelets, and erythrocytes, but reported on mouse monocytes and NK cells.

CD229 interacts homophilically through its N-terminal domain and localizes to the contact site between T cells and antigen-presenting B cells during antigen-dependent immune synapse formation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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