Thermo Fisher Scientific RKHD1 Polyclonal Antibody
Human RKHD1 단백질을 인식하는 Rabbit Polyclonal Antibody. IHC(P)에서 1:50–1:200 희석으로 사용 가능. 항원 친화 크로마토그래피로 정제된 액상 항체. PBS/glycerol buffer에 보관하며, 단기 4°C, 장기 -20°C 저장 권장. 연구용 전용 제품.
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- PA564220
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- pk
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Applications and Tested Dilution
- Immunohistochemistry (Paraffin) (IHC (P)): 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human RKHD1. Recombinant protein control fragment (Product #RP-103599) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.05 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2646587 |
Product Specific Information
- Immunogen sequence: DVFAGFAPHP AALGPPTLLA DQMSVICGRK K
- Highest antigen sequence identity: Mouse - 77%, Rat - 77%
Target Information
Rkhd1, also known as TINO or MEX3D, is a member of a novel family of four homologous human MEX3 proteins, each containing two heterogeneous nuclear ribonucleoprotein K homology (KH) domains and one carboxy-terminal RING finger module.
MEX3 proteins, including Rkhd1, are phosphoproteins that bind RNA through their KH domains and shuttle between the nucleus and cytoplasm via the CRM1 export pathway. These proteins are evolutionarily conserved RNA-binding proteins involved in post-transcriptional regulatory mechanisms.
Rkhd1 binds to the AU-rich element in the 3′-untranslated region of Bcl-2 mRNA and is thought to be a negative regulator of Bcl-2 expression. Rkhd3 and Rkhd4, but not Rkhd1, co-localize with both the hDcp1a decapping factor and Argonaute (Ago) proteins in processing bodies (P bodies), which are centers of mRNA turnover.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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