Thermo Fisher Scientific RKHD1 Polyclonal Antibody

Applications and Tested Dilution

• Immunohistochemistry (Paraffin) (IHC (P)): 1:50–1:200

Product Specifications

Product Specific Information

• Immunogen sequence: DVFAGFAPHP AALGPPTLLA DQMSVICGRK K
• Highest antigen sequence identity: Mouse - 77%, Rat - 77%

Target Information

Rkhd1, also known as TINO or MEX3D, is a member of a novel family of four homologous human MEX3 proteins, each containing two heterogeneous nuclear ribonucleoprotein K homology (KH) domains and one carboxy-terminal RING finger module.
MEX3 proteins, including Rkhd1, are phosphoproteins that bind RNA through their KH domains and shuttle between the nucleus and cytoplasm via the CRM1 export pathway. These proteins are evolutionarily conserved RNA-binding proteins involved in post-transcriptional regulatory mechanisms.
Rkhd1 binds to the AU-rich element in the 3′-untranslated region of Bcl-2 mRNA and is thought to be a negative regulator of Bcl-2 expression. Rkhd3 and Rkhd4, but not Rkhd1, co-localize with both the hDcp1a decapping factor and Argonaute (Ago) proteins in processing bodies (P bodies), which are centers of mRNA turnover.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.