Thermo Fisher Scientific ABCA5 Polyclonal Antibody
ABCA5 단백질을 인식하는 Rabbit Polyclonal 항체로, WB, IHC, ICC/IF, ELISA 등 다양한 응용에 사용 가능. Human, Mouse, Rat 반응성. Protein A 정제, 1 mg/mL 농도. -20°C 보관, 연구용 전용 제품.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | Assay-dependent |
| Immunohistochemistry (Frozen) (IHC-F) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Item | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human ABCA5, amino acids 1401–1500 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS with 50% glycerol, 1% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
ABCA5 (ATP-binding cassette, sub-family A (ABC1), member 5) is a 1,642 amino acid protein belonging to the ABC transporter superfamily and the ABCA family. The ABC1 subfamily is the only major ABC subfamily exclusive to multicellular eukaryotes. It is ubiquitously expressed, with high expression in testis, skeletal muscle, kidney, liver, and placenta. ABCA5 is a multi-pass membrane protein containing two ABC transporter domains and exists as three alternatively spliced isoforms. It exhibits membrane subcellular localization and may play a role in processing autolysosomes. Spanning 80 kb, ABCA5 contains 39 exons, with exon 2 containing the putative translation start site. ABCA5 maps to human chromosome 17q24 and is linked to lysosomal diseases. It may play roles in tumor development, cardiomyocyte and follicular cell activities, and could serve as a specific urine marker for diagnosing patients with high-grade prostatic intraepithelial neoplasia (HGPIN).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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