Thermo Fisher Scientific AHR Polyclonal Antibody
Thermo Fisher Scientific의 AHR Polyclonal Antibody는 인간 AHR 단백질을 인식하는 토끼 유래 IgG 항체로, IHC(P) 등 다양한 연구용 응용에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, 고순도 액상 형태로 제공됩니다. 장기 보관 시 -20°C에서 안정적으로 유지됩니다.
- 카탈로그번호
- PA532665
- 판매단위
- pk
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Applications
Immunohistochemistry (Paraffin) [IHC (P)]
- Tested Dilution: 6 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic 16 amino acid peptide from N-terminus of human Aryl Hydrocarbon Receptor |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.1% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2550128 |
Product Specific Information
- Percent identity with other species by BLAST analysis:
Human, Gorilla (100%); Gibbon, Monkey, Horse (94%); Marmoset, Bovine (88%); Bat, Dog, Hamster, Panda, Guinea pig (81%) - For IHC(P), use heat-induced antigen retrieval in pH 6.0 citrate buffer.
- After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen.
Target Information
AHR (Ah Receptor) belongs to a family of proteins that includes its dimerization partner ARNT (HIF-1 Beta) and the Drosophila proteins PER and SIM.
AHR contains an N-terminal PAS domain (~200 amino acids) and binds specific DNA enhancer sequences to initiate transcription of cytochrome P-450 (CYPIA1) mRNA.
It acts as a ligand-activated transcription factor regulating biological responses to planar aromatic hydrocarbons.
Known ligands include polycyclic and halogenated aromatic compounds such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD).
In non-ligand activated cells, AHR is complexed with HSP90 in the cytoplasm. Upon ligand binding, AHR transforms into a nuclear DNA-binding form, dissociates from HSP90, and forms a heterodimer with Arnt.
Diseases associated with AHR include eosinophilic fasciitis and seborrheic dermatitis.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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