Thermo Fisher Scientific BTK Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:1,000–1:10,000

Immunocytochemistry (ICC/IF)

• Tested Dilution: 1:100–1:1,000

Product Specifications

Product Specific Information

• Keep as concentrated solution.
• Predicted reactivity: Mouse (97%), Rat (97%), Pig (98%), Chicken (81%), Bovine (98%).
• Positive Control: Raji.
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

Bruton tyrosine kinase (BTK) is a cytoplasmic tyrosine kinase belonging to the SRC-related TEC subfamily of tyrosine kinases.
Mutations in the BTK gene have been linked to severe developmental blocks in human B-cell ontogeny and immunodeficiency disorders.
BTK interacts with members of the toll-like receptor (TLR) family such as TLR4, 6, 8, and 9, which are critical in both innate and adaptive immunity.
It also interacts with key proteins involved in TLR4 signal transduction, including MyD88, TIRAP, and IRAK, but not TRAF-6, suggesting involvement in lipopolysaccharide signal transduction.

⚠ WARNING
This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.