Thermo Fisher Scientific MAP4K1 Monoclonal Antibody (1G6)
MAP4K1(HPK1) 단백질을 인식하는 Mouse IgG1 모노클론 항체. Western blot 및 ELISA에 적합하며, 인간 시료 반응성. PBS 용액 형태로 제공되며, -20°C에서 보관. 연구용으로만 사용 가능.
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Thermo Fisher Scientific MAP4K1 Monoclonal Antibody (1G6)
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–5 µg/mL |
| ELISA | 0.03 ng/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 1G6 |
| Immunogen | MAP4K1 (NP_009112, 278–377 a.a.) partial recombinant protein with GST tag (MW of GST tag: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
GLNRGLILDL LDKLKNPGKG PSIGDIEDEE PELPPAIPRR IRSTHRSSSL GIPDADCCRR HMEFRKLRGM ETRPPANTAR LQPPRDLRSS SPRKQLSESS
Target Information
MAP4K1 (also known as HPK1) or Hematopoietic progenitor kinase 1 is a hematopoietic cell-restricted member of the Ste20 serine/threonine kinase superfamily.
MAP4K1 acts as a tissue-specific upstream activator of the MEKK/JNK/SAPK signaling pathway. It diminishes T cell receptor (TCR) signaling activity and T cell proliferation by phosphorylating the adaptor protein SLP-76.
The JNKs/SAPKs play a crucial role in stress responses in mammalian cells. Understanding this pathway is important for elucidating blood cell differentiation mechanisms. HPK1 is expressed predominantly in hematopoietic progenitor cells and activates JNK1 specifically, enhancing AP-1-mediated transcriptional activity.
HPK1 binds and phosphorylates MEKK1 directly, with JNK1 activation inhibited by dominant-negative MEKK1 or MKK4/SEK mutants. Unlike PAK65, HPK1 lacks the Rac1/Cdc42-binding domain, indicating it does not interact with these small GTPases.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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