Thermo Fisher Scientific NAE1 Polyclonal Antibody
Human, Mouse, Rat에 반응하는 Rabbit Polyclonal NAE1 항체로 Western blot 및 IHC(P) 검증됨. 항원 친화 크로마토그래피로 정제되었으며 PBS 기반 버퍼에 40% glycerol 포함. Alzheimer 연구 등 세포주기 관련 연구용에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human NAE1. Recombinant protein control fragment (Product # RP-98684) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2644434 |
Product Specific Information
Immunogen sequence:
PSFWILARAL KEFVAKEGQG NLPVRGTIPD MIADSGKYIK LQNVYREKAK KDAAAVGNHV AKLLQSIGQA PESISEKELK LLCSNSAFLR VVRCRSLAEE YGLDTINKDE
Highest antigen sequence identity to the following orthologs:
- Mouse: 96%
- Rat: 96%
Target Information
The protein encoded by this gene binds to the beta-amyloid precursor protein, a cell surface protein with signal-transducing properties, implicated in the pathogenesis of Alzheimer’s disease.
It can form a heterodimer with UBE1C and bind and activate NEDD8, a ubiquitin-like protein. This protein is required for cell cycle progression through the S/M checkpoint.
Three transcript variants encoding different isoforms have been identified for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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