Thermo Fisher Scientific NFE2 Polyclonal Antibody
Rabbit polyclonal antibody targeting human NFE2 for WB and IHC(P) applications. Validated for human samples with high specificity. Supplied as liquid, 0.05 mg/mL in PBS with 40% glycerol. Store at 4°C short term, -20°C long term. For research use only.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human NFE2. Recombinant protein control fragment (Product # RP-100710) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.05 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2644640 |
Product Specific Information
Immunogen sequence:
SRNRVIQLST SELGEMELTW QEIMSITELQ GLNAPSEPSF EPQAPAPYLG PPPPTTYCPC SIHPDSGFPL PPPPYELPAS TSHVPDPPYS YGNMAIPVSK PLSLSGLLSE PLQDPLALLD IGLPAGPPKP QEDPES
Highest antigen sequence identity to the following orthologs:
- Mouse: 82%
- Rat: 85%
Target Information
Component of the NF-E2 complex essential for regulating erythroid and megakaryocytic maturation and differentiation. Binds to the hypersensitive site 2 (HS2) of the beta-globin control region (LCR). This subunit (NFE2) recognizes the TCAT/C sequence of the AP-1-like core palindrome present in a number of erythroid and megakaryocytic gene promoters. Requires MAFK or other small MAF proteins for binding to the NF-E2 motif. May play a role in all aspects of hemoglobin production from globin and heme synthesis to procurement of iron.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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