Thermo Fisher Scientific NFE2 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

0.04-0.4 µg/mL

-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human NFE2. Recombinant protein control fragment (Product #RP-100710). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:NFE2,uniProtId:Q16621-1,ncbiNodeId:9606,antigenRange:9-144,antigenLength:373,antigenImageFileName:PA5-51659_NFE2_Q16621-1_Rabbit.svg,antigenImageFileNamePDP:PA5-51659_NFE2_Q16621-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.05 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2644640

Product Specific Information

Immunogen sequence: SRNRVIQLST SELGEMELTW QEIMSITELQ GLNAPSEPSF EPQAPAPYLG PPPPTTYCPC SIHPDSGFPL PPPPYELPAS TSHVPDPPYS YGNMAIPVSK PLSLSGLLSE PLQDPLALLD IGLPAGPPKP QEDPES

Highest antigen sequence identity to the following orthologs: Mouse - 82%, Rat - 85%.

Target Information

Component of the NF-E2 complex essential for regulating erythroid and megakaryocytic maturation and differentiation. Binds to the hypersensitive site 2 (HS2) of the beta-globin control region (LCR). This subunit (NFE2) recognizes the TCAT/C sequence of the AP-1-like core palindrome present in a number of erythroid and megakaryocytic gene promoters. Requires MAFK or other small MAF proteins for binding to the NF-E2 motif. May play a role in all aspects of hemoglobin production from globin and heme synthesis to procurement of iron.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.