Thermo Fisher Scientific HNF6 Polyclonal Antibody
HNF6 단백질을 인식하는 Rabbit Polyclonal Antibody로, Western blot과 IHC(P)에서 검증됨. 항원 친화 크로마토그래피로 정제되었으며 PBS 기반 완충액에 보관. 인간 시료에 반응하며, 연구용으로만 사용 가능.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human HNF6. Recombinant protein control fragment (Product #RP-100744). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2642490 |
Product Specific Information
Immunogen sequence:
SMNNLYTPYH KDVAGMGQSL SPLSSSGLGS IHNSQQGLPH YAHPGAAMPT DKMLTPNGFE
AHHPAMLGRH GEQHLTPTSA GMVPINGLPP HHPHAHLNAQ GHGQLLGTAR EPNPSVTGAQ
VSNGSNSGQM EEINTKEVHighest antigen sequence identity to the following orthologs:
- Mouse: 99%
- Rat: 99%
Target Information
Hepatocyte nuclear factor 6 (HNF6) is a CUT homeobox family protein and transcription factor containing both CUT and homeobox DNA-binding domains. It regulates multiple genes involved in the pathogenesis of maturity-onset diabetes of the young (MODY). HNF6 acts as a ligand of the FOXM1 transcription factor network and, together with HNF4, controls liver gene expression. Expression levels of HNF6 and HNF4 increase during development, and their regulation affects g6pc gene expression timing.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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