Thermo Fisher Scientific HCMV IL-10 Polyclonal Antibody
HCMV IL-10에 특이적인 염소 유래 폴리클로날 항체로, Western blot과 중화 실험에 적합합니다. 바이러스 면역 회피 기전을 연구하는 데 유용하며, 항원 친화 크로마토그래피로 정제되었습니다. 동결건조 형태로 제공되며, 재구성 후 -20°C에서 보관합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.1 µg/mL |
| Neutralization (Neu) | 0.15–0.9 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Virus |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | E. coli-derived recombinant viral HCMV IL-10 (Ala26–Lys176) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with 5% trehalose |
| Contains | No Preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2610677 |
Product Specific Information
- In direct ELISAs, less than 1% cross-reactivity with recombinant mouse, canine, feline, cotton rat, rat, porcine, human IL-10, and Epstein-Barr virus IL-10 has been observed.
- Reconstitute at 0.2 mg/mL in sterile PBS.
- Endotoxin level: <0.10 EU per 1 µg of antibody (LAL method).
Target Information
Interleukin-10 (IL-10) is a pleiotropic cytokine that plays a crucial role in regulating immune and inflammatory responses.
Human cytomegalovirus (HCMV), a prevalent pathogen capable of latent infection, encodes a homolog of IL-10 (HCMV IL-10) to modulate host immune responses.
HCMV IL-10 shares approximately 27% amino acid identity with human IL-10 but retains the ability to bind the human IL-10 receptor complex and induce signal transduction.
It suppresses cytokine production, inhibits proliferation of mitogen-stimulated human peripheral blood mononuclear cells, and downregulates antigen-presenting functions of monocytes, contributing to viral immune evasion.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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