Thermo Fisher Scientific PDE8A Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:2,000–1:10,000

Immunoprecipitation (IP)

• Tested Dilution: 2–5 µg/mg lysate

Product Specifications

Product Specific Information

The recommended shelf life for this product is 1 year from the date of receipt.

Target Information

Phosphodiesterases (PDEs) regulate intracellular levels of cAMP and cGMP. These cyclic nucleotides act as second messengers in multiple physiological processes, including regulation of vascular resistance, cardiac output, visceral motility, immune response, inflammation, neuroplasticity, vision, and reproduction.
PDEs form a large superfamily of enzymes divided into 10 families, distinguishable by structure, tissue expression, localization, substrate specificity, regulation, and inhibitor sensitivity. Their diversity makes them promising targets for pharmacotherapy of diseases modulated by cyclic nucleotide signaling (Hetman et al., 2000).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.