Thermo Fisher Scientific SETD6 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

0.04-0.4 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human SETD6. Recombinant protein control fragment (Product #RP-98545). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:SETD6,uniProtId:Q8TBK2-1,ncbiNodeId:9606,antigenRange:167-239,antigenLength:473,antigenImageFileName:PA5-59588_SETD6_Q8TBK2-1_Rabbit.svg,antigenImageFileNamePDP:PA5-59588_SETD6_Q8TBK2-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2647168

Product Specific Information

Immunogen sequence: LLQGTGVPEA VEKDLANIRS EYQSIVLPFM EAHPDLFSLR VRSLELYHQL VALVMAYSFQ EPLEEEEDEK EPN

Highest antigen sequence identity to the following orthologs: Mouse - 88%, Rat - 90%.

Target Information

SETD6 (SET domain-containing protein 6) is a 473 amino acid protein that belongs to the SETD6 family. Containing one SET domain, SETD6 is structurally similar to the Rubisco large subunit methyltransferase. SETD6 is a proteinlysine N-methyltransferase that specifically monomethylates Lys-310 of the NFκB p65 subunit of NFκB complex, leading to down-regulate NFκB transcription factor activity. SETD6-mediated methylation renders NFκB p65 inert and attenuates NFκB p65-driven transcriptional programs, including inflammatory responses in primary immune cells. The SETD6-initiated lysine-methylation signaling cascade acts to restrain activation of NFκB-mediated inflammatory responses in diverse cell types.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.