Thermo Fisher Scientific PDCD6 Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

• Recommended positive controls: HeLa, HeLa nucleus
• Predicted reactivity: Mouse (99%), Rat (98%), Zebrafish (88%), Xenopus laevis (86%), Bovine (99%)
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

An increased intracellular Ca²⁺ concentration induces apoptotic cell death. Transiently elevated Ca²⁺ concentrations are required for glucocorticoid-mediated and T cell receptor-mediated pathways, leading to T cell apoptosis. ALG-2 (apoptosis-linked gene 2) is a Ca²⁺-binding protein that participates in regulatory events occurring late in the apoptotic program, where several death signals converge. ALG-2 is expressed in normal brain and more strongly in ischemic brain. The ALG-2 protein contains five EF-hand-like motifs and shares homology with members of the penta EF-hand family, including Calpain small subunits sorcin and Grancalcin.

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.