Thermo Fisher Scientific LETMD1 Polyclonal Antibody, MaxPab

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG

Class

Polyclonal

Type

Antibody

Immunogen

LETMD1 (NP_056231.3, 1 a.a. approximately 360 a.a) full-length human protein. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:LETMD1,uniProtId:Q6P1Q0-1,ncbiNodeId:9606,antigenRange:1-360,antigenLength:360,antigenImageFileName:H00025875-B01P_LETMD1_Q6P1Q0-1_House_mouse.svg,antigenImageFileNamePDP:H00025875-B01P_LETMD1_Q6P1Q0-1_House_mouse_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

See Label

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4

Contains

no preservative

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Sequence of this protein is as follows: MALSRVCWAR SAVWGSAVTP GHFVTRRLQL GRSGLAWGAP RSSKLHLSPK ADVKNLMSYV VTKTKAINGK YHRFLGRHFP RFYVLYTIFM KGLQMLWADA KKARRIKTNM WKHNIKFHQL PYREMEHLRQ FRQDVTKCLF LGIISIPPFA NYLVFLLMYL FPRQLLIRHF WTPKQQTDFL DIYHAFRKQS HPEIISYLEK VIPLISDAGL RWRLTDLCTK IQRGTHPAIH DILALRECFS NHPLGMNQLQ ALHVKALSRA MLLTSYLPPP LLRHRLKTHT TVIHQLDKAL AKLGIGQLTA QEVKSACYLR GLNSTHIGED RCRTWLGEWL QISCSLKEAE LSLLLHNVVL LSTNYLGTRR

Target Information

HCCR-1 (human cervical cancer oncogene 1), also known as HCCR-2 or LETMD1, is a 360 amino acid single-pass membrane protein that is expressed in the kidney, liver, skeletal muscle, heart and brain. It is suggested that HCCR-1 may be involved in tumorigenesis and may function as a negative regulator of the p53 tumor suppressor. Overexpression of HCCR-1 may cause mitochondrial dysfunction that can lead to UVC or staurosporine-induced apoptosis resistance and progression of tumor formation. HCCR-1 is considered a candidate biomarker for breast cancer. Various human tumors including leukemia, lymphoma, and carcinomas of the breast, kidney, ovary, stomach, colon, and uterine cervix have high HCCR-1. Six isoforms exist due to alternative splicing events.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.