Thermo Fisher Scientific FOXO1A Monoclonal Antibody (2F12)
FOXO1A 단백질을 표적으로 하는 Thermo Fisher Scientific의 Mouse Monoclonal Antibody (Clone 2F12). Western blot, ICC/IF, ELISA에 사용 가능. Human 종에 반응하며 PBS 용액 형태로 제공. 연구용으로만 사용.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–5 µg/mL |
| Immunocytochemistry (ICC/IF) | 15 µg/mL |
| ELISA | 10 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b, lambda |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 2F12 |
| Immunogen | FOXO1A (NP_002006, 452 a.a. approximately 555 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
msqyncapgl lkelltsdsp phndimtpvd pgvaqpnsrv lgqnvmmgpn svmstygsqa shnkmmnpss hthpghaqqt savngrplph tvstmphtsg mnrl
Target Information
FOXO1 (FKHR, Forkhead Box O1) is a member of the forkhead homeotic gene family of transcription factors. It can act as a coactivator or corepressor of nuclear receptor activity mediated through the LXXLL motif in the carboxyl terminal region.
Association of FOXO1 with PAX3 has been implicated in alveolar rhabdomyosarcoma. Studies link FOXO1 to anti-tumor activity, autophagy, and myogenic growth and differentiation.
FOXO1 is the main target of insulin signaling regulating metabolic homeostasis under oxidative stress. It binds to the insulin response element (IRE) and the Daf-16 family binding element (DBE).
FOXO1 regulates redox balance, osteoblast numbers, and bone mass, orchestrating skeletal endocrine function in glucose metabolism. In hepatocytes, FOXO1 promotes gluconeogenesis by activating genes such as IGFBP1, G6PC, and PPCK1.
FOXO1 is an important regulator of cell death acting downstream of CDK1, PKB/AKT1, and SKT4/MST1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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