Thermo Fisher Scientific Krt222 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

Immunogen sequence:
VDEVIKEWEGS FFKDNPRLRK KSVSLRFDLH LAATDEGCLE TKQDNLPDIE VRLIMRRSCS IPSIKPPST

Highest antigen sequence identity to the following orthologs: mouse 94%, rat 94%.

Target Information

KRT222 (also known as KRT222P):
KRT222 is a 295 amino acid protein belonging to the intermediate filament family. The gene encoding KRT222P has been listed as a pseudogene, but it has not been conclusively shown that the protein is not translated, and it is therefore treated as a protein-coding gene.

It exists as two alternatively spliced isoforms and maps to human chromosome 17, which comprises over 2.5% of the human genome and encodes over 1,200 genes.

Two key tumor suppressor genes are associated with chromosome 17 — p53 and BRCA1:

• p53: Maintains cellular genetic integrity by balancing DNA repair and apoptosis. Loss or malfunction is linked to malignant growth and Li-Fraumeni syndrome.
• BRCA1: Involved in DNA repair and associated with early-onset breast cancer and predisposition to ovarian, colon, prostate, and fallopian tube cancers.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.