Thermo Fisher Scientific Krt222 Polyclonal Antibody
Rabbit polyclonal antibody recognizing human Krt222 protein. Validated for ICC/IF applications. Supplied as liquid, unconjugated form with 0.05 mg/mL concentration. Stored in PBS with glycerol and sodium azide. For research use only.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Human Krt222. Recombinant protein control fragment (Product # RP-107713) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.05 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2664024 |
Product Specific Information
Immunogen sequence:
VDEVIKEWEGS FFKDNPRLRK KSVSLRFDLH LAATDEGCLE TKQDNLPDIE VRLIMRRSCS IPSIKPPST
Highest antigen sequence identity to the following orthologs: mouse 94%, rat 94%.
Target Information
KRT222 (also known as KRT222P):
KRT222 is a 295 amino acid protein belonging to the intermediate filament family. The gene encoding KRT222P has been listed as a pseudogene, but it has not been conclusively shown that the protein is not translated, and it is therefore treated as a protein-coding gene.
It exists as two alternatively spliced isoforms and maps to human chromosome 17, which comprises over 2.5% of the human genome and encodes over 1,200 genes.
Two key tumor suppressor genes are associated with chromosome 17 — p53 and BRCA1:
- p53: Maintains cellular genetic integrity by balancing DNA repair and apoptosis. Loss or malfunction is linked to malignant growth and Li-Fraumeni syndrome.
- BRCA1: Involved in DNA repair and associated with early-onset breast cancer and predisposition to ovarian, colon, prostate, and fallopian tube cancers.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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