Thermo Fisher Scientific Caveolin 1 Polyclonal Antibody
Caveolin-1 단백질을 표적하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, WB, IHC, ICC, Flow Cytometry 등 다양한 응용에 적합. Caveolin-2/-3 비교반응성 없음. 고순도 항원 친화 크로마토그래피 정제, 연구용 전용.
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Thermo Fisher Scientific Caveolin 1 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000 | View 2 publications |
| Immunohistochemistry (IHC) | - | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:250 | View 1 publication |
| Immunocytochemistry (ICC/IF) | 1:400 | View 3 publications |
| Flow Cytometry (Flow) | 1:50 | - |
| Immunoprecipitation (IP) | 1:50 | View 1 publication |
| Miscellaneous PubMed (Misc) | - | View 1 publication |
Product Specifications
| Item | Description |
|---|---|
| Species Reactivity | Bovine, Chicken, Hamster, Human, Mouse, Pig, Rat, Zebrafish |
| Published Species | Dog, Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to residues surrounding Glu20 of human caveolin-1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 33 µg/mL |
| Purification | Antigen affinity chromatography, Protein A |
| Storage Buffer | 0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol |
| Contains | No preservative |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10985023 |
Product Specific Information
- It is not recommended to aliquot this antibody.
- This antibody is not cross-reactive with caveolin-2 or -3.
Target Information
Caveolin-1 (CAV1) is a scaffolding protein within caveolar membranes. It interacts directly with G-protein alpha subunits and can functionally regulate their activity. Caveolin-1 is also involved in co-stimulatory signaling essential for T-cell receptor (TCR) mediated T-cell activation.
It binds with DPP4 and induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner.
Mutations affecting the CAV1 gene can result in congenital generalized lipodystrophy 3, pulmonary hypertension primary 3, or partial lipodystrophy/congenital cataracts and neurodegeneration syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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(이미지 파일: PA5-17447_Caveolin_1_Q03135-1_Rabbit.svg, PA5-17447_Caveolin_1_Q03135-1_Rabbit_PDP.jpeg)
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