Thermo Fisher Scientific E-cadherin Monoclonal Antibody (SHE78-7)
Thermo Fisher E-cadherin Monoclonal Antibody (SHE78-7)은 인간 E-cadherin을 인식하는 Mouse IgG2a 형 단일클론 항체입니다. WB, IHC, ICC, Flow, ELISA 등 다양한 응용에 적합하며, Lyophilized 형태로 제공됩니다. 암 연구 및 세포 접착 관련 연구에 활용됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 2 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 2 µg/mL |
| Immunocytochemistry (ICC/IF) | Assay-dependent |
| Flow Cytometry (Flow) | 1 µg/mL |
| ELISA | 2 µg/mL |
| Inhibition Assays (IA) | 1 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | SHE78-7 |
| Immunogen | Human placenta E-Cadherin |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 0.5–1.0 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Reconstitute in distilled water to the final desired concentration.
Target Information
E-Cadherin (epithelial cadherin) is a classical cadherin belonging to the calcium-dependent adhesion protein superfamily. It is a cell-cell adhesion glycoprotein composed of five extracellular cadherin repeats, a transmembrane region, and a conserved cytoplasmic tail. Mutations in the CDH1 gene encoding E-cadherin are associated with various cancers, including gastric, breast, colorectal, thyroid, and ovarian cancers. Loss of E-cadherin function contributes to cancer progression through increased proliferation, invasion, and metastasis. The protein plays a key role in maintaining tissue architecture and integrity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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