Thermo Fisher Scientific NUAK2 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

-

ELISA (ELISA)

1 µg/mL

-

Product Specifications

Species Reactivity

Human, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 479-628 of human NUAK2 (NP_1122143) if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:NUAK2,uniProtId:Q9H093-1,ncbiNodeId:9606,antigenRange:479-628,antigenLength:628,antigenImageFileName:PA5-88040_NUAK2_Q9H093-1_Rabbit.svg,antigenImageFileNamePDP:PA5-88040_NUAK2_Q9H093-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.61 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2804610

Product Specific Information

Immunogen sequence: VSGDPKEQKP PQASGLLLHR KGILKLNGKF SQTALELAAP TTFGSLDELA PPRPLARASR PSGAVSEDSI LSSESFDQLD LPERLPEPPL RGCVSVDNLT GLEEPPSEGP GSCLRRWRQD PLGDSCFSLT DCQEVTATYR QALRVCSKLT; Positive Samples: Rat liver

Target Information

NUAK2 or SNF1/AMP kinase-related kinase (SNARK) is a member of the NUAK family of SNF1-like kinase 2. NUAK2 is activated by muscle contraction and is a unique mediator of contraction-stimulated glucose transport in skeletal muscle (1). NUAK2 is involved in cellular stress responses linked to obesity and type 2 diabetes. NUAK2 shows kinase activity against a synthetic test peptide and the activity in keratinocytes is increased by AMP and 5-amino-4-imidazolecarboxamide riboside, implying that AMPK kinase-dependent pathway can activate NAUK2. Glucose deprivation also increases NAUK2 activity in baby hamster kidney fibroblasts.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.