Thermo Fisher Scientific SLC51B Polyclonal Antibody
Rabbit polyclonal antibody against human SLC51B for WB and IHC applications. Recognizes recombinant human SLC51B protein. Supplied as liquid, unconjugated form, purified by antigen affinity chromatography. Suitable for bile acid transporter research.
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Applications
Western Blot (WB)
- Tested Dilution: 0.04–0.4 µg/mL
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:20–1:50
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human SLC51B. Recombinant protein control fragment (Product # RP-88590) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2647535 |
Product Specific Information
Immunogen sequence:
VLHLDEAKDH NSLNNLRETL LSEKPNLAQV ELELKERDVL SVFLPDVPET E
Highest antigen sequence identity to the following orthologs:
- Mouse: 60%
- Rat: 56%
Target Information
The heteromeric transporter OST Alpha/OST Beta facilitates the transport of bile and other steroid solutes across the basolateral epithelial cell membrane of intestine, liver, testis, kidney, and adrenal gland. OST Alpha/OST Beta expression is induced by bile acids through ligand-dependent transactivation of their genes by FXR (Farnesoid X-activated receptor). This regulation suggests that bile acids adjust their own efflux rate from enterocytes in response to intracellular bile acid levels. OST Beta is a 128 amino acid single-pass transmembrane protein that requires OST Alpha for plasma membrane localization and proper glycosylation. Coexpression facilitates trafficking of OST Alpha through the Golgi apparatus. OST Beta is most highly expressed in the ileum.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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