Thermo Fisher Scientific FOLR3 Monoclonal Antibody (OTI6C1), TrueMAB
FOLR3 단백질을 인식하는 마우스 모노클로날 항체로, Western blot과 파라핀 절편 면역조직화학에 적합합니다. Human 시료에 반응하며, Affinity chromatography로 정제된 1 mg/mL 액상 제품입니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI6C1 |
| Immunogen | Full length human recombinant protein of human FOLR3 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Target Information
Folate is an essential vitamin that must be obtained from food intake through intestinal absorption in mammals. Folate and reduced folic acid derivatives bind to the folate receptor (FR) family, which mediates the endocytosis of 5-methyltetrahydrofolate into the cell.
The folate receptors consist of five members: alpha, beta, gamma, gamma′ (produced by alternative splicing), and delta.
- β-FR is attached to the membrane by a GPI anchor and is expressed in malignant tissues of epithelial and nonepithelial origin.
- γ-FR is expressed in tissues of hematopoietic origin, such as spleen, thymus, and bone marrow.
- δ-FR expression is highly restricted both spatially and temporally.
The α isoform of the folate receptor is used as a highly selective tumor marker and may be targeted for the delivery of therapeutic compounds to tumor cells by coupling to derivatives of folic acid.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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배송/결제/교환/반품 안내
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