Thermo Fisher Scientific ULBP1 Polyclonal Antibody

Product Specifications

Product Specific Information

Immunogen sequence:
THCLCYDFII TPKSRPEPQW CEVQGLVDER PFLHYDCVNH KAKAFASLGK KVNVTKTWEE QTETLRDVVD FLKGQLLDIQ VENLIPIEPL TLQARMS

Target Information

ULBP1 is the ligand for the NKG2D receptor, together with at least ULBP2 and ULBP3. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway.
In CMV infected cells, ULBP1 interacts with soluble CMV glycoprotein UL16. This interaction blocks the binding with the NKG2D receptor, providing a mechanism by which CMV-infected cells might escape the immune system. UL16 also causes ULBP1 to be retained in the ER and cis-Golgi apparatus, preventing its expression on the cell surface.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.