Thermo Fisher Scientific Phospho-GAB2 (Tyr643) Polyclonal Antibody
GAB2 단백질의 Tyr643 인산화 형태를 특이적으로 인식하는 Rabbit Polyclonal 항체. Western blot 및 Immunohistochemistry에 적합. Human, Mouse, Rat 반응성. 고순도 정제, -20°C 보관.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Immunohistochemistry (PFA fixed) (IHC (PFA))
- Tested Dilution: 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human GAB2 (Accession Q9UQC2), corresponding to amino acid residues around phosphorylated Tyr643 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage buffer | PBS with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2899316 |
Product Specific Information
Antibody detects endogenous levels of Gab2 only when phosphorylated at tyrosine 643.
Target Information
This gene is a member of the GRB2-associated binding protein (GAB) gene family. These proteins contain pleckstrin homology (PH) domains and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. They act as adapters for transmitting various signals in response to stimuli through cytokine and growth factor receptors, and T- and B-cell antigen receptors. The protein encoded by this gene is the principal activator of phosphatidylinositol-3 kinase in response to activation of the high affinity IgE receptor. Two alternatively spliced transcripts encoding different isoforms have been described for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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