Thermo Fisher Scientific Cullin 4B Polyclonal Antibody

Applications

• Western Blot (WB): Tested dilution 1:500–1:3,000

Product Specifications

Product Specific Information

• Recommended positive controls: Target recombinant protein
• Predicted reactivity: Human (99%), Mouse (98%), Rat (99%), Zebrafish (93%), Xenopus laevis (90%), Cat (98%)
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

Cullin 4B is a core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes that mediate ubiquitination and proteasomal degradation of target proteins. It functions as a scaffold protein, positioning substrates and ubiquitin-conjugating enzymes to facilitate catalysis.
CUL4B participates in polyubiquitination of CDT1, histone H2A, H3, and H4 following DNA damage, and is targeted to UV-damaged chromatin by DDB2, playing an important role in DNA repair and replication. It is required for cyclin E ubiquitination and normal G1 cell cycle progression, and regulates the mTOR pathway controlling cell growth and metabolism. CUL4B’s regulation of mTORC1 depends on 26S proteasome function and interaction with MLST8.

⚠ WARNING: This product can expose you to chemicals including mercury, known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

제품 이미지

(해당 제품 관련 이미지가 있을 경우 여기 배치)