Thermo Fisher Scientific Cullin 4B Polyclonal Antibody
Rabbit polyclonal antibody against human Cullin 4B for Western blot applications. Recognizes multiple species with high predicted reactivity. Provided as a liquid, unconjugated form purified by antigen affinity chromatography. Suitable for research use...
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific Cullin 4B Polyclonal Antibody
Applications
- Western Blot (WB): Tested dilution 1:500–1:3,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein fragment corresponding to amino acids 592–887 of Human Cullin 4B |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.33 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.1M Tris glycine, pH 7, with 20% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2547330 |
Product Specific Information
- Recommended positive controls: Target recombinant protein
- Predicted reactivity: Human (99%), Mouse (98%), Rat (99%), Zebrafish (93%), Xenopus laevis (90%), Cat (98%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Cullin 4B is a core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes that mediate ubiquitination and proteasomal degradation of target proteins. It functions as a scaffold protein, positioning substrates and ubiquitin-conjugating enzymes to facilitate catalysis.
CUL4B participates in polyubiquitination of CDT1, histone H2A, H3, and H4 following DNA damage, and is targeted to UV-damaged chromatin by DDB2, playing an important role in DNA repair and replication. It is required for cyclin E ubiquitination and normal G1 cell cycle progression, and regulates the mTOR pathway controlling cell growth and metabolism. CUL4B’s regulation of mTORC1 depends on 26S proteasome function and interaction with MLST8.
⚠ WARNING: This product can expose you to chemicals including mercury, known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(해당 제품 관련 이미지가 있을 경우 여기 배치)
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.