Thermo Fisher Scientific FPGS Polyclonal Antibody
Human FPGS를 인식하는 Rabbit Polyclonal Antibody로, IHC(P)에서 1:1,000~1:2,500 희석으로 사용 가능. 항원 친화 크로마토그래피로 정제된 액상 시약이며, PBS/40% glycerol buffer에 보존. 세포 내 폴리글루타메이션 연구에 적합.
- 카탈로그번호
- PA562197
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific FPGS Polyclonal Antibody
Applications
- Immunohistochemistry (Paraffin) (IHC (P)): Tested dilution 1:1,000–1:2,500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human FPGS. Recombinant protein control fragment (Product #RP-98445). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2641727 |
Product Specific Information
Immunogen sequence:
RVLLFNATGD RDPAALLKLL QPCQFDYAVF CPNLTEVSST GNADQQNFTV TLDQVLLRCL EHQQHWNHLD EEQASPDLWS APSPEPGGSA SLLL
Highest antigen sequence identity to orthologs:
- Mouse: 80%
- Rat: 74%
Target Information
Folylpoly-gamma-glutamate synthetase (FPGS) catalyzes the addition of several equivalents of glutamic acid to the gamma-carboxyl group in the side chain of folate cofactors and analogs.
FPGS has three key functions in folate homeostasis in mammals:
- Polyglutamation prevents efflux of folate cofactors from the cell.
- It enhances binding of folate cofactors to enzymes of folate interconversion and biosynthesis.
- It facilitates accumulation of folates in mitochondria required for glycine synthesis.
FPGS is widely expressed in human tumors and is associated with cell proliferation or lack of differentiation. Its integrative function contributes to the efficiency of folate antimetabolites, impacting cytotoxicity of thymidylate synthase and purine inhibitors.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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