Thermo Fisher Scientific TMEM38A Polyclonal Antibody
Human TMEM38A 단백질을 인식하는 Rabbit Polyclonal 항체로, WB 및 IHC(P) 실험에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, PBS/glycerol buffer에 보존됩니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human TMEM38A. Recombinant protein control fragment (Product #RP-100827). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.05 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2648691 |
Product Specific Information
Immunogen sequence:
THSHSSPFDA LEGYICPVLF GSACGGDHHH DNHGGSHSGG GPGAQHSAMP AKSKEELSEG SRKK
Highest antigen sequence identity to orthologs:
- Mouse: 78%
- Rat: 78%
Target Information
TMEM38A and TMEM38B are trimeric intracellular cation (TRIC) channel subtypes.
TMEM38A is preferentially expressed in excitable tissues such as striated muscle and brain, localizing to the sarcoplasmic reticulum (SR) in muscle tissues.
Mice deficient in both TMEM38A and TMEM38B exhibit embryonic cardiac failure with severe SR Ca²⁺ handling dysfunction, weakened Ca²⁺ release, and reduced K⁺ permeability.
These findings suggest TRIC channels function as counter-ion channels synchronized with Ca²⁺ release from intracellular stores.
TMEM38A and TMEM38B also act with junctophilin proteins to support efficient ryanodine receptor-mediated Ca²⁺ release in muscle cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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