Thermo Fisher Scientific HGS Monoclonal Antibody (OTI1C2), TrueMAB

Applications

• Western Blot (WB): Tested dilution 1:2,000

Product Specifications

Product Specific Information

For reconstitution, add 100 µL of distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).

Target Information

HGS is involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. It may act as a direct effector of PI3-kinase in vesicular pathways via early endosomes and regulate trafficking to early and late endosomes by recruiting clathrin. HGS may concentrate ubiquitinated receptors within clathrin-coated regions and is involved in down-regulation of receptor tyrosine kinases via multivesicular bodies (MVBs) when complexed with STAM. This complex binds ubiquitin and acts as sorting machinery that transfers ubiquitinated receptors to lysosomal degradation pathways. HGS may also facilitate recruitment of SMADs to the activin receptor complex.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.