Thermo Fisher Scientific ARID1A/BAF250 Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

• Recommended shelf life: 1 year from date of receipt
• Based on 100% sequence identity, this antibody is predicted to react with Mouse

Target Information

This gene encodes a member of the SWI/SNF family, whose members have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, required for transcriptional activation of genes normally repressed by chromatin. It possesses at least two conserved domains important for function:

1. A DNA-binding domain that specifically binds an AT-rich DNA sequence recognized by the SNF/SWI complex at the beta-globin locus.
2. A C-terminal domain that can stimulate glucocorticoid receptor-dependent transcriptional activation.

The encoded protein confers specificity to the SNF/SWI complex and may recruit it to targets through protein-DNA or protein-protein interactions. Two transcript variants encoding different isoforms have been identified.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.