Thermo Fisher Scientific Aurora A Kinase Monoclonal Antibody (ZY191)
Aurora A kinase 단백질을 인식하는 mouse monoclonal antibody (Clone ZY191). Western blot 및 IHC(P) 검증 완료. Human 및 Mouse 반응성. Protein A로 정제된 0.5 mg/mL 액상 항체로, 단기 4°C, 장기 -20°C 보관 권장. 연구용 전용 시약.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.1–1 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 2–10 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | ZY191 |
| Immunogen | Recombinant full-length human Aurora A kinase protein (amino acids 1–403) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS with proprietary stabilizer |
| Contains | 0.01% sodium azide |
| Storage Conditions | Store at 4°C for short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive control: Breast carcinoma
- Cellular location: Nucleus
Target Information
AURKA (Aurora A) is a serine/threonine kinase that regulates mitosis by association with centrosomes. Overexpression of AURKA is observed in many types of cancer. Aurora A plays a key role in cell cycle regulation during anaphase and telophase, particularly in the centrosome/spindle pole region during chromosome segregation.
It is overexpressed in various human cancers including breast, ovarian, and colorectal cancers, and is considered a potential target for anticancer drug development.
Tissue specificity: Highly expressed in testis, weakly in skeletal muscle, thymus, and spleen.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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